Fotemustine Combined with Procarbazine in Recurrent Malignant Gliomas: A Phase I Study with Evaluation of Lymphocyte O6-alkylguanine–DNA Alkyltransferase Activity

Abstract

The aims of this phase I study in patients with recurrent malignant gliomas were to determine the maximum tolerated dose (MTD) and toxicity profile of fotemustine when combined with a fixed dose of procarbazine (PCZ), and to evaluate the extent of O 6-alkylguanine–DNA alkyltransferase (ATase) depletion in circulating lymphocytes during treatment. Sixteen… (More)
DOI: 10.1023/A:1010626421709

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@article{Boiardi2001FotemustineCW, title={Fotemustine Combined with Procarbazine in Recurrent Malignant Gliomas: A Phase I Study with Evaluation of Lymphocyte O6-alkylguanine–DNA Alkyltransferase Activity}, author={Amerigo Boiardi and Antonio Silvani and Emilio Ciusani and Amanda Watson and Geoffrey P. Margison and Elisabeth Berger and Catherine J Lucas and Bruno Giroux}, journal={Journal of Neuro-Oncology}, year={2001}, volume={52}, pages={149-156} }