Fossils, genes and the evolution of animal limbs

@article{Shubin1997FossilsGA,
  title={Fossils, genes and the evolution of animal limbs},
  author={Neil H. Shubin and Clifford J. Tabin and Sean B. Carroll},
  journal={Nature},
  year={1997},
  volume={388},
  pages={639-648}
}
The morphological and functional evolution of appendages has played a crucial role in the adaptive radiation of tetrapods, arthropods and winged insects. The origin and diversification of fins, wings and other structures, long a focus of palaeontology, can now be approached through developmental genetics. Modifications of appendage number and architecture in each phylum are correlated with regulatory changes in specific patterning genes. Although their respective evolutionary histories are… 
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  • 2011
TLDR
Instead of emphasizing the subset of developmental genes, for instance Hoxd genes, the focus here is on the significance of elucidating cis‐regulatory elements for multiple other key molecular players of limb/fin development and genetic/molecular interactions among them, for a better understanding of the developmental and genetic basis of limb evolution.
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