Fosaprepitant dimeglumine (MK-0517 or L-785,298), an intravenous neurokinin-1 antagonist for the prevention of chemotherapy induced nausea and vomiting.

@article{VanBelle2008FosaprepitantD,
  title={Fosaprepitant dimeglumine (MK-0517 or L-785,298), an intravenous neurokinin-1 antagonist for the prevention of chemotherapy induced nausea and vomiting.},
  author={Simon Van Belle and V{\'e}ronique F. Cocquyt},
  journal={Expert opinion on pharmacotherapy},
  year={2008},
  volume={9 18},
  pages={
          3261-70
        }
}
BACKGROUND This paper reviews the existing literature on fosaprepitant, an intravenous neurokinin-1 anatgonist for the prevention of chemotherapy induced nausea and vomiting. OBJECTIVES To describe the development of fosaprepitant and to situate the intravenous form of aprepitant in the current market of available antiemetics. METHODS Literature was screened and selected in order to compare the intravenous form of the already commonly used NK-1 receptor antagonist aprepitant. RESULTS… 
A Randomized Controlled Pilot Study Comparing the Impact of Aprepitant and Fosaprepitant on Chemotherapy Induced Nausea and Vomiting in Patients Treated for Gynecologic Cancer
TLDR
The findings from the current analysis suggest that intravenous fosaprepitant and oral aprepitant confer beneficial antiemetic prevention and theoretically afford a favorable impact on daily living, thereby potentially facilitating the completion of a patient’s clinically prescribed chemotherapy regimen.
MANAGEMENT OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING
Abstract Chemotherapy-induced nausea and vomiting (CINV) remains one of the most disturbing side effects of cancer treatment. Research in anti-emetic therapy progressed gradually since the early
Validation of Stability-Indicating Reverse Phase HPLC Method for the Determination of Related Substances in Fosaprepitant Dimeglumine Drug Substance
A gradient reversed phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for the determination of related substances of Fosaprepitant dimeglumine drug
Product Data Sheet Chemical Properties Product
Chemical Name: N,N,2-trimethyl-5-nitrobenzenesulfonamide Canonical SMILES: CC1=C(S(N(C)C)(=O)=O)C=C(N(=O)=O)C=C1 Solubility: Soluble in DMSO Storage: Store at -20°C General tips: For obtaining a