FosB is Highly Expressed in Normal Mammary Epithelia, but Down-Regulated in Poorly Differentiated Breast Carcinomas

@article{MildeLangosch2004FosBIH,
  title={FosB is Highly Expressed in Normal Mammary Epithelia, but Down-Regulated in Poorly Differentiated Breast Carcinomas},
  author={Karin Milde-Langosch and Holger Kappes and Sabine Riethdorf and Thomas L{\"o}ning and Ana-maria Bamberger},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={77},
  pages={265-275}
}
FosB is a member of the AP-1 family of transcription factors which represent important regulators of cell proliferation and differentiation. Based on prior results which indicated a role of FosB in breast cancer, we studied FosB protein and mRNA expression by immunohistochemistry and, partly, in situ hybridization in 68 mammary carcinomas and normal breast tissues. We found strong nuclear FosB immunoreactivity in epithelial cells of normal lobules and ducts, whereas carcinomas frequently showed… 
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