FosB is Highly Expressed in Normal Mammary Epithelia, but Down-Regulated in Poorly Differentiated Breast Carcinomas

@article{MildeLangosch2004FosBIH,
  title={FosB is Highly Expressed in Normal Mammary Epithelia, but Down-Regulated in Poorly Differentiated Breast Carcinomas},
  author={Karin Milde-Langosch and Holger Kappes and Sabine Riethdorf and Thomas L{\"o}ning and Ana-maria Bamberger},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={77},
  pages={265-275}
}
FosB is a member of the AP-1 family of transcription factors which represent important regulators of cell proliferation and differentiation. Based on prior results which indicated a role of FosB in breast cancer, we studied FosB protein and mRNA expression by immunohistochemistry and, partly, in situ hybridization in 68 mammary carcinomas and normal breast tissues. We found strong nuclear FosB immunoreactivity in epithelial cells of normal lobules and ducts, whereas carcinomas frequently showed… 
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It is shown that the concentration of Fra-1 is high in invasive oestrogen receptor (ER)-negative (ER−) breast cancer cell lines, regardless of their Ras pathway status, and that PKCθ could participate in progression of some breast cancers and could be a new therapeutic target.
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Comparison with the expression of formerly analysed cell-cycle- and invasion-associated proteins corroborates the conclusion that activation of ERK1 and ERK2 is not associated with enhanced proliferation and invasion of mammary carcinomas.
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The data presented here support the E2-ERα-mediated MCF-7 cell proliferation and confirms the role of AP-1 factors in cell cycle regulation.
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Interestingly, high FosB levels were significantly associated with MMP1 overexpression, whereas expression of c-Fos and phosphorylated Fra-1 correlated with M MP9 protein levels.
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