Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaB.

@article{Takada2010FosPS,
  title={Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaB.},
  author={Yasunari Takada and Neelanjan Ray and Eiji Ikeda and Tomohiro Kawaguchi and Masayoshi Kuwahara and Erwin F Wagner and Koichi Matsuo},
  journal={Journal of immunology},
  year={2010},
  volume={184 2},
  pages={1014-21}
}
The Fos family proteins, c-Fos and Fra-1, are components of the dimeric transcription factor AP-1, which is typically composed of Fos and Jun family proteins. We have previously shown that mice lacking c-Fos (Fos(-/-) mice) respond more strongly to LPS injection than do wild-type (wt) controls. We then examined the sensitivity of Fos(-/-) mice to acute inflammatory stress in a dextran sulfate sodium (DSS)-induced colitis model. We found that Fos(-/-) mice exhibited more severe weight loss… CONTINUE READING

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