Fos induction following systemic kainic acid: early expression in hippocampus and later widespread expression correlated with seizure.

@article{Willoughby1997FosIF,
  title={Fos induction following systemic kainic acid: early expression in hippocampus and later widespread expression correlated with seizure.},
  author={John O. Willoughby and Lorraine Mackenzie and Andrei V. Medvedev and Jennifer Hiscock},
  journal={Neuroscience},
  year={1997},
  volume={77 2},
  pages={379-92}
}
We determined the distribution of Fos protein expression in a model of generalised epilepsy caused by excessive neuronal excitation. Fos immunoreactivity was mapped in forebrain in unrestrained rats, previously prepared with an indwelling venous catheter, after the intravenous administration of kainic acid (10 mg/kg). We determined cerebral activation… CONTINUE READING