Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats.

@article{Mahler2012FosAO,
  title={Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats.},
  author={Stephen V Mahler and Gary S. Aston-Jones},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 38},
  pages={13309-26}
}
Ventral tegmental area (VTA) dopamine neurons are crucial for appetitive responses to Pavlovian cues, including cue-induced reinstatement of drug seeking. However, it is unknown which VTA inputs help activate these neurons, transducing stimuli into salient cues that drive drug-seeking behavior. Here we examined 56 VTA afferents from forebrain and midbrain that are Fos activated during cue-induced reinstatement. We injected the retrograde tracer cholera toxin β subunit (CTb) unilaterally into… CONTINUE READING