Fos-B expression is required for polyamine-induced increase in nuclear activator protein-1 DNA binding in discrete structures of murine brain.

@article{Inoue2003FosBEI,
  title={Fos-B expression is required for polyamine-induced increase in nuclear activator protein-1 DNA binding in discrete structures of murine brain.},
  author={Keiji Inoue and Nobuyuki Kuramoto and Chie Sugiyama and Hideo Taniura and Katsumi Sakata and Yoshiaki Fujinami and Kiyokazu Ogita and Yukio Yoneda},
  journal={Journal of neuroscience research},
  year={2003},
  volume={74 2},
  pages={199-209}
}
Spermidine (SPD) and spermine (SPN) have been shown to be endogenous agonists for N-methyl-D-aspartate (NMDA) receptors that could lead to expression of the nuclear transcription factor activator protein-1 (AP1) complex in the mammalian central nervous system both in vitro and in vivo. In nuclear extracts of murine whole brain, AP1 DNA binding increased significantly in a concentration-dependent manner with the addition of either SPD or SPN at a concentration range of 50-500 microM. Similarly… CONTINUE READING