Forward engineering neuronal diversity using direct reprogramming.

  title={Forward engineering neuronal diversity using direct reprogramming.},
  author={Rachel K. Tsunemoto and Kevin T. Eade and Joel W. Blanchard and Kristin K. Baldwin},
  journal={The EMBO journal},
  volume={34 11},
The nervous system is comprised of a vast diversity of distinct neural cell types. Differences between neuronal subtypes drive the assembly of neuronal circuits and underlie the subtype specificity of many neurological diseases. Yet, because neurons are irreversibly post-mitotic and not readily available from patients, it has not been feasible to study specific subtypes of human neurons in larger numbers. A powerful means to study neuronal diversity and neurological disease is to establish… CONTINUE READING
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