Forward and reverse genetic approaches to synaptogenesis.

@article{Broadie1998ForwardAR,
  title={Forward and reverse genetic approaches to synaptogenesis.},
  author={Kendal Broadie},
  journal={Current opinion in neurobiology},
  year={1998},
  volume={8 1},
  pages={128-38}
}
Genetic approaches at the neuromuscular synapse are leading investigation into the mechanisms of synaptogenesis. The marriage of classical (forward) and reverse genetic techniques allows the isolation and analysis of novel proteins involved in synaptic maturation and the functional in vivo characterization of previously identified synaptic proteins. Of particular interest are recent advances using mouse reverse genetics and Drosophila forward genetics.