Forward and feedback regulation of cyclic steroid production in Drosophila melanogaster.

  title={Forward and feedback regulation of cyclic steroid production in Drosophila melanogaster.},
  author={Jean-Philippe Parvy and Peng Wang and Damien Garrido and Annick Maria and Catherine Blais and Mickael Poidevin and Jacques Montagne},
  volume={141 20},
In most animals, steroid hormones are crucial regulators of physiology and developmental life transitions. Steroid synthesis depends on extrinsic parameters and autoregulatory processes to fine-tune the dynamics of hormone production. In Drosophila, transient increases of the steroid prohormone ecdysone, produced at each larval stage, are necessary to trigger moulting and metamorphosis. Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential… CONTINUE READING
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