Forward Signaling Mediated by Ephrin-B3 Prevents Contralateral Corticospinal Axons from Recrossing the Spinal Cord Midline

@article{Yokoyama2001ForwardSM,
  title={Forward Signaling Mediated by Ephrin-B3 Prevents Contralateral Corticospinal Axons from Recrossing the Spinal Cord Midline},
  author={Nobuhiko Yokoyama and Mario I. Romero and Chad A. Cowan and Pedro Ochoa Galv{\'a}n and Françoise Helmbacher and Patrick Charnay and Luis F. Parada and Mark Henkemeyer},
  journal={Neuron},
  year={2001},
  volume={29},
  pages={85-97}
}
To investigate Eph-ephrin bidirectional signaling, a series of mutations were generated in the ephrin-B3 locus. The absence of both forward and reverse signaling resulted in mice with mirror movements as typified by a hopping locomotion. The corticospinal tract was defective as axons failed to respect the midline boundary of the spinal cord and bilaterally innervated both contralateral and ipsilateral motor neuron populations. A second mutation that expresses a truncated ephrin-B3 protein… CONTINUE READING
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