Forty years with homologous recombination

  title={Forty years with homologous recombination},
  author={O. Smithies},
  journal={Nature Medicine},
  • O. Smithies
  • Published 2001
  • Biology, Medicine
  • Nature Medicine
  • cation as a geneticist, this was soon proven correct. The field of normal human protein polymorphic variants was seeded! The hereditary variations we had discovered proved to be in the hemoglobin-binding serum protein haptoglobin, and their details were worked out during a happy collaboration between George E. Connell, Gordon H. Dixon and me in the early 1960s. The haptoglobin alleles Hp1F (fast) and Hp1S (slow) encoded polypeptides differing by two amino acids, but the third allele, Hp2… CONTINUE READING
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