Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS.

@article{Zaidi2002FortyYO,
  title={Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS.},
  author={M Shoaib Zaidi and Angela M. Inzerillo and Baljit S. Moonga and Peter J. R. Bevis and Christopher L.-H. Huang},
  journal={Bone},
  year={2002},
  volume={30 5},
  pages={655-63}
}
Calcitonin was discovered as a hypocalcemic principal that was initially thought to originate from the parathyroid gland. This view was corrected subsequently, and an origin from the thyroid C cells was documented. The purification and sequencing of various calcitonins soon followed. Calcitonin is a 32-amino-acid-long peptide with an N-terminal disulfide bridge and a C-terminal prolineamide residue. The peptide was shown to potently inhibit bone resorption; however, a direct osteoclastic action… CONTINUE READING

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