Forte of Bioinformatic Computational Tools in Identification of Targets of Digitalis in Unicellular Eukaryotes : Featuring Acanthamoeba Castellanii

Abstract

Membrane Na+K+ATPase is a known target of the drug digoxin, which is a cardiotropic agent prescribed for congestive heart failure and certain arrhythmias in clinical practice. The drug in humans binds and inhibits the cell membrane Na+K+ATPase and a mitochondrial enzyme cytochrome P450-11A1. Recently, digoxin has been shown to exert anti-amoebic effects… (More)

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