Forskolin stimulates cyclic AMP synthesis, lowers intraocular pressure and increases outflow facility in rabbits.

@article{Bartels1982ForskolinSC,
  title={Forskolin stimulates cyclic AMP synthesis, lowers intraocular pressure and increases outflow facility in rabbits.},
  author={Stephen P. Bartels and Sang Ryeul Lee and Arrhur H. Neufeld},
  journal={Current eye research},
  year={1982},
  volume={2 10},
  pages={673-81}
}
The intracellular pathway by which beta-adrenergic agonists and antagonists affect aqueous humor dynamics involves the intracellular mediator, cyclic AMP. We have therefore tested the activity of forskolin, a direct activator of adenylate cyclase, in rabbits. Following a 15 min in vitro incubation in the presence of forskolin (15 microM) and isobutylmethylxanthine, a 10 fold increase in cyclic AMP was found in both rabbit iris-ciliary body and scleral-trabecular rings relative to controls… CONTINUE READING
20 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…