Forskolin enhances in vivo bone formation by human mesenchymal stromal cells.

Abstract

Activation of the protein kinase A (PKA) pathway with dibutyryl cyclic adenosine monophosphate (db-cAMP) was recently shown to enhance osteogenic differentiation of human mesenchymal stromal cells (hMSCs) in vitro and bone formation in vivo. The major drawback of this compound is its inhibitory effect on proliferation of hMSCs. Therefore, we investigated… (More)
DOI: 10.1089/ten.TEA.2011.0312

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