Forskolin's effect on transient K current in nudibranch neurons is not reproduced by cAMP.

  title={Forskolin's effect on transient K current in nudibranch neurons is not reproduced by cAMP.},
  author={James Coombs and Shelley Thompson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={7 2},
Forskolin, a diterpene extracted from Coleus forskolii, stimulates the production of cAMP in a variety of cells and is potentially an important tool for studying the role of cAMP in the modulation of neuronal excitability. We studied the effects of forskolin on neurons of nudibranch molluscs and found that it caused characteristic, reversible changes in the amplitude and waveform of the transient K current, IA, and also activated an inward current similar to the cAMP-dependent inward current… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 21 extracted citations


Publications referenced by this paper.
Showing 1-10 of 40 references

Three uharmacoloaicallv distinct uotassium channels’in molluscan’neurons

  • S H.Thomnson.
  • J. Physiol.(Lonh.)
  • 1977
Highly Influential
4 Excerpts

Direct anestheticlike effects of forskolin on the nicotinic acetylcholine receptors of PC 12 cells

  • E. J. Nestler
  • J . Biol . Chem .
  • 1986

Peptidergic neurons of ApZysiu lose their response to CAMP during a prolonged refractory period

  • M. B. Kennedy
  • J . Neurosci .
  • 1985

Similar Papers

Loading similar papers…