Formyltetrahydrofolates associated with mitochondria have longer polyglutamate chains than the methyltetrahydrofolates associated with cytoplasm in rat brain.

@article{Carl1996FormyltetrahydrofolatesAW,
  title={Formyltetrahydrofolates associated with mitochondria have longer polyglutamate chains than the methyltetrahydrofolates associated with cytoplasm in rat brain.},
  author={G. Carl and F. Hudson and B. S. McGuire},
  journal={The Journal of nutrition},
  year={1996},
  volume={126 12},
  pages={
          3077-82
        }
}
  • G. Carl, F. Hudson, B. S. McGuire
  • Published 1996
  • Biology, Medicine
  • The Journal of nutrition
  • The subcellular distribution of folate coenzymes in the brain is unknown. Brain folate concentrations are low and hence require a sensitive assay to determine the subcellular distribution. Rat brain was fractionated by differential centrifugation into cytoplasmic, mitochondrial and crude synaptosomal fractions. The compositions of the folate pools in these subcellular fractions were determined by differential conversion of one-carbon forms enzymatically to 5,10-methylenetetrahydrofolate (5… CONTINUE READING
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