Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

@article{Rivire2009FormylPR,
  title={Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors},
  author={St{\'e}phane Rivi{\`e}re and Ludivine Challet and Daniela Fluegge and Marc Spehr and Ivan Rodriguez},
  journal={Nature},
  year={2009},
  volume={459},
  pages={574-577}
}
Mammals rely heavily on olfaction to interact adequately with each other and with their environment. They make use of seven-transmembrane G-protein-coupled receptors to identify odorants and pheromones. These receptors are present on dendrites of olfactory sensory neurons located in the main olfactory or vomeronasal sensory epithelia, and pertain to the odorant, trace amine-associated receptor and vomeronasal type 1 (ref. 4) or 2 (refs 5–7) receptor superfamilies. Whether these four sensor… Expand
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Signaling in the Mammalian Vomeronasal Organ
TLDR
It is shown that the two classes of vomeronasal receptors V1Rs and V2Rs use different strategies to encode chemosensory information, and possible roles for the FPRs include the assessment of conspecifics or other species, based on variability in normal bacterial or mitochrondrial proteins. Expand
A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction
TLDR
It is reported that members of the four-pass transmembrane MS4A protein family are chemosensors expressed within necklace sensory neurons, which define a distinct mechanism and functional logic for mammalian olfaction. Expand
Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors
TLDR
It is shown that calreticulin, a housekeeping chaperone commonly expressed in most eukaryotic cells, is sparsely expressed in the vomeronasal sensory neurons (VSNs) and postulate that V2Rs may use a unique trafficking mechanism whereby an important and more commonly expressed chaper one is deleterious for membrane export and is replaced by a functionally equivalent homolog that does not inhibit export while carrying out its functions. Expand
Evolution of Chemosensory Receptor Genes in Primates and Other Mammals
TLDR
It appears that the repertoires of chemosensory receptor genes in each species are largely determined by the needs from each species living environment, and the reduction of repertoire sizes in primates would reflect their reliance on vision rather than olfaction. Expand
Strain-specific Loss of Formyl Peptide Receptor 3 in the Murine Vomeronasal and Immune Systems*
TLDR
In vitro calcium imaging and immunofluorescence analyses demonstrate that the lack of four amino acids leads to an unstable, truncated, and non-functional receptor protein, which provides a foundation for understanding the in vivo function of Fpr3. Expand
The genomic basis of vomeronasal-mediated behaviour
TLDR
The vomeronasal organ mediates a range of social behaviours, including male–male and maternal aggression, sexual attraction, lordosis, and selective pregnancy termination, as well as interspecific responses such as avoidance and defensive behaviours. Expand
Family structure and phylogenetic analysis of odorant receptor genes in the large yellow croaker (Larimichthys crocea)
TLDR
About 100 OR genes are shown to be expressed in the olfactory epithelial tissues of L. crocea, and the result of real-time PCR shows that different clades of ORs have distinct expression levels. Expand
Amphioxus (Branchiostoma floridae) has orthologs of vertebrate odorant receptors
TLDR
The identification of vertebrate OR orthologs in amphioxus will lead to an improved understanding of OR gene family evolution, OR gene function, and the mechanisms that control cell-specific expression, axonal guidance, signal transduction and signal integration. Expand
Structure and function of a peptide pheromone family that stimulate the vomeronasal sensory system in mice.
TLDR
The discovery of a 7 kDa peptide, ESP1 (exocrine-gland-secreting peptide 1), in tear fluids from male mice that enhances the sexual behaviour of female mice via the VNO and a structural basis for the narrowly tuned perception of mammalian peptide pheromones by vomeronasal receptors is indicated. Expand
Formyl Peptide Receptors from Immune and Vomeronasal System Exhibit Distinct Agonist Properties*
TLDR
It is shown that the vomeronasal receptor mFpr-rs1 can be activated robustly by W-peptide and structural derivatives but not by other typical ligands of immune Fprs, which is consistent with a role in vomer onasal pathogen sensing. Expand
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References

SHOWING 1-10 OF 23 REFERENCES
A novel family of genes encoding putative pheromone receptors in mammals
TLDR
Sequence analysis indicates that a family of about 30 putative receptor genes comprise a novel family of seven transmembrane domain proteins unrelated to the receptors expressed in the MOE, likely to encode mammalian pheromone receptors. Expand
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
TLDR
A novel multigene family that codes for a diverse array of candidate pheromone receptors (VRs) expressed by the G alpha(o)+ subset is identified, suggesting a distributed mode of sensory coding. Expand
A New Multigene Family of Putative Pheromone Receptors
TLDR
A new multigene family of G protein-linked receptors (V2Rs) that are specifically expressed in the VNO that are related to the Ca2+-sensing receptor and metabotropic glutamate receptors. Expand
Ultrasensitive pheromone detection by mammalian vomeronasal neurons
TLDR
This work uses a mouse VNO slice preparation to show that six putative pheromones evoke excitatory responses in single vomeronasal neurons, leading to action potential generation and elevated calcium entry, providing a basis for understanding chemical signals that regulate mammalian communication and sexual behaviour. Expand
A second class of chemosensory receptors in the olfactory epithelium
TLDR
The evolutionary conservation of the TAAR family suggests a chemosensory function distinct from odorant receptors, and ligands identified for TAARs thus far suggest a function associated with the detection of social cues. Expand
Arachidonic Acid Plays a Role in Rat Vomeronasal Signal Transduction
TLDR
Evidence is provided for a role of PUFAs in rat vomeronasal signal transduction by application of urine and the possible role of polyunsaturated fatty acids (PUFAs) as intracellular messengers in freshly dissociated rat VNO neurons. Expand
Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses.
TLDR
The physiological role of the FPR family is still incompletely understood, due in part to the large variety of ligands, the redundancy with other chemoattractant agents, and the lack of clear orthologs between human and mouse receptors. Expand
[A molecular basis for odorant recognition: olfactory receptor pharmacology].
TLDR
It is shown that mOR-EG, a mouse olfactory receptor that was isolated from a eugenol-responsive cell, recognizes 22 different odorants with EC50 values ranging from a few microM to several hundred microM, and rational receptor design with predicted ligand specificity is succeeded by introducing point mutations in the binding site, confirming the accuracy of thebinding site mapping. Expand
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
TLDR
This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors. Expand
Sulfated Steroids as Natural Ligands of Mouse Pheromone-Sensing Neurons
TLDR
Urine concentrations of the two sulfated glucocorticoids increased many fold in stressed animals, indicating that information about physiological status is encoded by the urine concentration of particular sulfated steroids. Expand
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