Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

@article{Rivire2009FormylPR,
  title={Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors},
  author={St{\'e}phane Rivi{\`e}re and Ludivine Challet and Daniela Fluegge and Marc Spehr and Ivan Rodriguez},
  journal={Nature},
  year={2009},
  volume={459},
  pages={574-577}
}
Mammals rely heavily on olfaction to interact adequately with each other and with their environment. They make use of seven-transmembrane G-protein-coupled receptors to identify odorants and pheromones. These receptors are present on dendrites of olfactory sensory neurons located in the main olfactory or vomeronasal sensory epithelia, and pertain to the odorant, trace amine-associated receptor and vomeronasal type 1 (ref. 4) or 2 (refs 5–7) receptor superfamilies. Whether these four sensor… 
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329 Citations

A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction
Signaling in the Mammalian Vomeronasal Organ
TLDR
It is shown that the two classes of vomeronasal receptors V1Rs and V2Rs use different strategies to encode chemosensory information, and possible roles for the FPRs include the assessment of conspecifics or other species, based on variability in normal bacterial or mitochrondrial proteins.
Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors
TLDR
It is shown that calreticulin, a housekeeping chaperone commonly expressed in most eukaryotic cells, is sparsely expressed in the vomeronasal sensory neurons (VSNs) and postulate that V2Rs may use a unique trafficking mechanism whereby an important and more commonly expressed chaper one is deleterious for membrane export and is replaced by a functionally equivalent homolog that does not inhibit export while carrying out its functions.
Evolution of Chemosensory Receptor Genes in Primates and Other Mammals
TLDR
It appears that the repertoires of chemosensory receptor genes in each species are largely determined by the needs from each species living environment, and the reduction of repertoire sizes in primates would reflect their reliance on vision rather than olfaction.
Strain-specific Loss of Formyl Peptide Receptor 3 in the Murine Vomeronasal and Immune Systems*
TLDR
In vitro calcium imaging and immunofluorescence analyses demonstrate that the lack of four amino acids leads to an unstable, truncated, and non-functional receptor protein, which provides a foundation for understanding the in vivo function of Fpr3.
The genomic basis of vomeronasal-mediated behaviour
TLDR
The vomeronasal organ mediates a range of social behaviours, including male–male and maternal aggression, sexual attraction, lordosis, and selective pregnancy termination, as well as interspecific responses such as avoidance and defensive behaviours.
Family structure and phylogenetic analysis of odorant receptor genes in the large yellow croaker (Larimichthys crocea)
TLDR
About 100 OR genes are shown to be expressed in the olfactory epithelial tissues of L. crocea, and the result of real-time PCR shows that different clades of ORs have distinct expression levels.
Amphioxus (Branchiostoma floridae) has orthologs of vertebrate odorant receptors
TLDR
The identification of vertebrate OR orthologs in amphioxus will lead to an improved understanding of OR gene family evolution, OR gene function, and the mechanisms that control cell-specific expression, axonal guidance, signal transduction and signal integration.
Structure and function of a peptide pheromone family that stimulate the vomeronasal sensory system in mice.
TLDR
The discovery of a 7 kDa peptide, ESP1 (exocrine-gland-secreting peptide 1), in tear fluids from male mice that enhances the sexual behaviour of female mice via the VNO and a structural basis for the narrowly tuned perception of mammalian peptide pheromones by vomeronasal receptors is indicated.
Formyl Peptide Receptors from Immune and Vomeronasal System Exhibit Distinct Agonist Properties*
TLDR
It is shown that the vomeronasal receptor mFpr-rs1 can be activated robustly by W-peptide and structural derivatives but not by other typical ligands of immune Fprs, which is consistent with a role in vomer onasal pathogen sensing.
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TLDR
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TLDR
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TLDR
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TLDR
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