Formulations of Fentanyl for the Management of Pain

@article{Grape2010FormulationsOF,
  title={Formulations of Fentanyl for the Management of Pain},
  author={Sina Grape and Professor Stephan A. Schug and Stefan Lauer and Barbara S. Schug},
  journal={Drugs},
  year={2010},
  volume={70},
  pages={57-72}
}
Fentanyl is an opioid initially developed for parenteral administration. While oral administration is not an option due to a high first-pass metabolism, its high potency and lipophilicity have made a number of new routes of administration feasible. The transdermal therapeutic system offers an excellent option for long-term treatment of cancer and chronic pain, achieving stable plasma concentrations over the treatment period. The recent change from reservoir to matrix systems has made these… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

Transdermal Fentanyl for Pain Management in Cancer Patients

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Fentanyl Pectin Nasal Spray

VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 102 REFERENCES

Clinical pharmacokinetics of fentanyl and its newer derivatives

LE Mather
  • Clin Pharmacokinet
  • 1983
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department

BorlandM, I Jacobs, B King
  • Ann Emerg Med
  • 2007
VIEW 1 EXCERPT