Formulation studies on modified releasing amoxicillin trihydrate microcapsules.

  title={Formulation studies on modified releasing amoxicillin trihydrate microcapsules.},
  author={Kandemir Canefe and S Ateşoğlu-G{\"o}çmez},
  journal={Bollettino chimico farmaceutico},
  volume={141 6},
In vitro researches and in vivo animal experiments show that, generally the antibiotic concentration should be above minimum inhibitory concentration for optimal efficiency. There is also direct and indirect evidence from human trials to support this claim. Consequently, a modified-release dosage form of the beta-lactam antibiotics might be therapeutically more efficient than the existing conventional products, which are rapidly absorbed to produce transient peaks in serum drug levels. In our… CONTINUE READING