Formulation optimization of long-acting depot injection of aripiprazole by using D-optimal mixture design.

@article{Nahata2009FormulationOO,
  title={Formulation optimization of long-acting depot injection of aripiprazole by using D-optimal mixture design.},
  author={Tushar Nahata and Tulsi Ram Saini},
  journal={PDA journal of pharmaceutical science and technology},
  year={2009},
  volume={63 2},
  pages={113-22}
}
Non-adherence to medication specifications is a major cause for poor outcomes in the therapy of schizophrenia. In situ implantable preparation of aripiprazole, an atypical antipsychotic drug, was intended with the aim to improve the patient compliance and to offer an effective antipsychotic drug therapy. D-optimal mixture design was employed to design and optimize long-acting depot injection of aripiprazole using polylactide-co-glycolide (PLGA) 50:50, 75:25, 85:15, and cholesterol as release… CONTINUE READING

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