Formulation of tretinoin-loaded topical proniosomes for treatment of acne: in-vitro characterization, skin irritation test and comparative clinical study.

@article{Rahman2015FormulationOT,
  title={Formulation of tretinoin-loaded topical proniosomes for treatment of acne: in-vitro characterization, skin irritation test and comparative clinical study.},
  author={Salwa M. Abdel Rahman and Nevine Shawky Abdelmalak and Alia Abd El-Latif Badawi and Tahany Elbayoumy and Nermeen Sabry and Amany El Ramly},
  journal={Drug delivery},
  year={2015},
  volume={22 6},
  pages={731-9}
}
Tretinoin (TRT) is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Therefore, the aim of this study was the development of TRT-loaded proniosomes to improve the drug efficacy and to increase user acceptability and compliance by reducing its side… CONTINUE READING
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Effect of different process variables on the preparation of baclofen niosomes

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