Formulation of the adenylate cyclase toxin of Bordetella pertussis as protein-coated microcrystals.

@article{Khosravani2007FormulationOT,
  title={Formulation of the adenylate cyclase toxin of Bordetella pertussis as protein-coated microcrystals.},
  author={Abdolmajid Khosravani and Marie-Claire Parker and Roger Parton and John Coote},
  journal={Vaccine},
  year={2007},
  volume={25 22},
  pages={
          4361-7
        }
}
Adenylate cyclase toxin (CyaA) is an important virulence factor of Bordetella pertussis, the causative agent of whooping cough, and, in its detoxified form, a potential component of acellular pertussis vaccines. This study reports the application of a novel technology, formulation of CyaA as protein-coated microcrystals (PCMC), to improve the performance of CyaA as a vaccine component. CyaA is normally stored in a high urea concentration to prevent aggregation and to maintain stability of the… CONTINUE READING