Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery.

Abstract

An optimised water-in-oil-in-water double emulsion process for the microencapsulation of plasmid DNA in poly(D,L-lactic-co-glycolic acid) (PLGA) was used to prepare microparticles from a range of different PLGA formulations. This process has been developed using pharmaceutically accepted solvents and is potentially scaleable. Incorporation of plasmid DNA in… (More)

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Cite this paper

@article{TinsleyBown2000FormulationOP, title={Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery.}, author={Anne Tinsley-Bown and Rachel Fretwell and A. Barry Dowsett and Stuart L. Davis and G. H. Farrar}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2000}, volume={66 2-3}, pages={229-41} }