Formulation of photocleavable liposomes and the mechanism of their content release.

@article{Chandra2006FormulationOP,
  title={Formulation of photocleavable liposomes and the mechanism of their content release.},
  author={Binita Chandra and Rajesh Subramaniam and Sanku Mallik and Dharmendra K. Srivastava},
  journal={Organic & biomolecular chemistry},
  year={2006},
  volume={4 9},
  pages={1730-40}
}
In pursuit of designing photocleavable liposomes as drug delivery vehicles, we synthesized several amphiphilic lipids by connecting stearyl amine (as the non-polar tail) and charged amino acids (as polar heads) via the o-nitrobenzyl derivatives. The lipids containing Glu, Asp, and Lys amino acids were subjected to photocleavage reaction by UV light, and the overall spectral changes of the chromophoric o-nitrobenzyl conjugates were determined as a function of time. The experimental data revealed… CONTINUE READING
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