Formulation of multiparticulate systems as lyophilised orally disintegrating tablets.

@article{Alhusban2011FormulationOM,
  title={Formulation of multiparticulate systems as lyophilised orally disintegrating tablets.},
  author={Farhan A Alhusban and Yvonne Perrie and Afzal R Mohammed},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2011},
  volume={79 3},
  pages={627-34}
}
The current study aimed to exploit the electrostatic associative interaction between carrageenan and gelatin to optimise a formulation of lyophilised orally disintegrating tablets (ODTs) suitable for multiparticulate delivery. A central composite face centred (CCF) design was applied to study the influence of formulation variables (gelatin, carrageenan and alanine concentrations) on the crucial responses of the formulation (disintegration time, hardness, viscosity and pH). The disintegration… CONTINUE READING

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