Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate.

@article{Yamaguchi2005FormulationOA,
  title={Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate.},
  author={Masazumi Yamaguchi and Shin-ichi Yasueda and Akiharu Isowaki and Makiko Yamamoto and Masako Kimura and Katsuhiro Inada and Akira Ohtori},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={301 1-2},
  pages={121-8}
}
Preparation of oil-in-water (o/w) type lipid emulsion is one of the approaches to formulate drugs that are poorly water-soluble but can be dissolved in the oil phase of the emulsions. A synthetic glucocorticoid medicine, difluprednate (DFBA), is a water-insoluble compound. We formulated DFBA (0.05%, w/v) ophthalmic lipid emulsion containing 5.0% (w/v) caster oil and 4.0% (w/v) polysorbate 80. The appearance of the emulsion was blue and translucent lipid emulsion, and the median particle size of… CONTINUE READING