Formulation of a reservoir-type testosterone transdermal delivery system.

  title={Formulation of a reservoir-type testosterone transdermal delivery system.},
  author={M K Kim and Hao Zhao and Chi Ho Lee and Dennis D Y Kim},
  journal={International journal of pharmaceutics},
  volume={219 1-2},
A reservoir-type transdermal delivery system of testosterone (TS) was developed using an ethanol/water (70:30) cosolvent system as the vehicle. The maximum permeation rate achieved by 70% (v/v) of ethanol was further increased from 2.69 to 47.83 microg/cm(2)/h with the addition of 1.0% dodecylamine as the skin permeation enhancer. The permeation rate of TS through the ethylene vinyl acetate (EVA) membrane was observed to increase as the vinyl acetate content in the copolymer increased. Addition… CONTINUE READING


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