Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability.

@article{Childs2013FormulationOA,
  title={Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability.},
  author={Scott L. Childs and Praveen Kandi and Sreenivas Reddy Lingireddy},
  journal={Molecular pharmaceutics},
  year={2013},
  volume={10 8},
  pages={3112-27}
}
Cocrystals have become an established and adopted approach for creating crystalline solids with improved physical properties, but incorporating cocrystals into enabling pre-clinical formulations suitable for animal dosing has received limited attention. The dominant approach to in vivo evaluation of cocrystals has focused on deliberately excluding additional formulation in favor of "neat" aqueous suspensions of cocrystals or loading neat cocrystal material into capsules. However, this study… CONTINUE READING
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