Formulation of Acid-Sensitive Micelles for Delivery of Cabazitaxel into Prostate Cancer Cells.

@article{Aydin2016FormulationOA,
  title={Formulation of Acid-Sensitive Micelles for Delivery of Cabazitaxel into Prostate Cancer Cells.},
  author={Omer Aydin and Ibrahim Abbas Youssef and Yasemin Yuksel Durmaz and Gopinath Tiruchinapally and Mohamed Hammad Elsayed},
  journal={Molecular pharmaceutics},
  year={2016},
  volume={13 4},
  pages={
          1413-29
        }
}
We report the synthesis of an amphiphilic triblock copolymer composed of a hydrophilic poly(ethylene glycol) (PEG) block, a central poly(acrylic acid) (PAA) block, and a hydrophobic poly(methyl methacrylate) (PMMA) block using atom transfer radical polymerization technique. We examined the self-assembly of PEG-b-PAA-b-PMMA copolymers in aqueous solutions forming nanosized micelles and their ability to encapsulate hydrophobic guest molecules such as Nile Red (NR) dye and cabazitaxel (CTX, an… CONTINUE READING
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