Formulation of 20(S)-protopanaxadiol nanocrystals to improve oral bioavailability and brain delivery.

Abstract

The aim of this study was to fabricate 20(S)-protopanaxadiol (PPD) nanocrystals to improve PPD's oral bioavailability and brain delivery. PPD nanocrystals were fabricated using an anti-solvent precipitation approach where d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was optimized as the stabilizer. The fabricated nanocrystals were nearly… (More)
DOI: 10.1016/j.ijpharm.2015.12.014

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