Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib.

@article{Subramanian2004FormulationDO,
  title={Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib.},
  author={Natesan Subramanian and Subhabrata Ray and Saroj Kumar Ghosal and Ranjan Bhadra and Satya Priya Moulik},
  journal={Biological & pharmaceutical bulletin},
  year={2004},
  volume={27 12},
  pages={1993-9}
}
Celecoxib is a hydrophobic and highly permeable drug belonging to class II of biopharmaceutics classification system. Low aqueous solubility of celecoxib leads to high variability in absorption after oral administration. Cohesiveness, low bulk density and compressibility, and poor flow properties of celecoxib impart complications in it's processing into solid dosage forms. To improve the solubility and bioavailability and to get faster onset of action of celecoxib, the self-microemulsifying… CONTINUE READING
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