Formulation-dependent pharmacokinetics and pharmacodynamics of propofol in rats.

  title={Formulation-dependent pharmacokinetics and pharmacodynamics of propofol in rats.},
  author={Suvendra N. Dutta and William F. Ebling},
  journal={The Journal of pharmacy and pharmacology},
  volume={50 1},
Propofol, a highly lipophilic anaesthetic, is commercially formulated as a lipid emulsion (diprivan) for intravenous use. This formulation is characterized by rapid onset and offset of effect after rapid intravenous administration and an effect-site equilibration half-life (t1/2kE0) of 1.7 min in rats. Paradoxically these characteristics are usually associated with relatively water-soluble anaesthetics. To test the influence of the formulation on propofol pharmacokinetics, effect-site… CONTINUE READING

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