Formulation and process optimization of multiparticulate pulsatile system delivered by osmotic pressure-activated rupturable membrane.


In this study, a multiparticulate pulsatile drug delivery system activated by a rupturable controlled-release membrane (Eudragit(®) RS) via osmotic pressure (with NaCl as the osmogent) was developed and characterized for omeprazole, omeprazole sodium, and propranolol HCl which have different water solubilities. Multiparticulates in pellet form for… (More)
DOI: 10.1016/j.ijpharm.2015.01.006


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