Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis.

@article{Moghddam2016FormulationAO,
  title={Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis.},
  author={Seyedeh Raziyeh Mahdavi Moghddam and Abdul Ahad and Mohd Aqil and Syed Sarim Imam and Yasmin Sultana},
  journal={Materials science & engineering. C, Materials for biological applications},
  year={2016},
  volume={69},
  pages={789-97}
}
This research aimed towards the design of preparations of diacerein loaded cholesterol rich niosomes by employing a 3-factor, 3-level Box-Behnken design. Results indicated that Span 60 (90mg) and cholesterol (10mg), and 45min of hydration time were found to be optimum for niosomes preparation. The prepared cholesterol rich niosomes were uniform and spherical in size. Optimized formulation F2 entrapped the drug with 83.02% efficiency in the cholesterol rich niosomes of the size 477.8nm… CONTINUE READING

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