Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion

@article{Sammour2008FormulationAO,
  title={Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion},
  author={O. Sammour and Mohammed A. Hammad and N. A. Megrab and A. Zidan},
  journal={AAPS PharmSciTech},
  year={2008},
  volume={7},
  pages={E167-E175}
}
The purpose of the present investigation was to increase the solubility and dissolution rate of rofecoxib by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 (PVP K30) using solvent evaporation method. Drug-polymer interactions were investigated using differential scanning calorimetry (DSC), x-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). For the preparation of rofecoxib mouth dissolve tablets, its 1∶9 solid dispersion with PVP K30 was used… Expand
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