Formulation and in vivo evaluation of sodium alendronate spray-dried microparticles intended for lung delivery.

@article{Cruz2011FormulationAI,
  title={Formulation and in vivo evaluation of sodium alendronate spray-dried microparticles intended for lung delivery.},
  author={Let{\'i}cia Cruz and Elias Fattal and Leandro Tasso and Gabrielle Coelho Freitas and Adriano B Carregaro and S{\'i}lvia Stanisçuaski Guterres and Adriana Raffin Pohlmann and Nicolas Tsapis},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={152 3},
  pages={
          370-5
        }
}
Spray-dried powders for lung delivery of sodium alendronate (SA) were prepared from hydroalcoholic solutions. Formulations display geometric particle size below to 12 μm and spherical shape associated to a hollow structure. The addition of leucine and ammonium bicarbonate leads to porous particles with rough surfaces. The tapped density ranges from 0.016 to 0.062 g/cm(3), decreasing with the increase of the leucine concentration. For all formulations, the calculated aerodynamic diameters are… CONTINUE READING

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