Formulation and ex vivo evaluation of rofecoxib gel for topical application.

  title={Formulation and ex vivo evaluation of rofecoxib gel for topical application.},
  author={Malay Kumar Das and Abdul Baquee Ahmed},
  journal={Acta poloniae pharmaceutica},
  volume={64 5},
The potential gastrointestinal disorders associated with oral administration of rofecoxib can be avoided by delivering the drug to the inflammation site at a sustained, concentrated level over an extended period of time. Hydroxypropylmethylcellulose (HPMC), sodium alginate and Carbopol 940 were used in an attempt to develop topical gel formulations of rofecoxib. The effects of polymer composition on the rate of drug release from the gel formulations were examined through cellulose membrane… CONTINUE READING
Highly Cited
This paper has 56 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 16 extracted citations

57 Citations

Citations per Year
Semantic Scholar estimates that this publication has 57 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 10 references

Drug Develop

P. R. Keshary, Y. W.Chien
Ind. Pharm. 10, 1663 • 1984
View 4 Excerpts
Highly Influenced


A. B. Ahmed
Pharm. Thesis, Dibrugarh University, India • 2006
View 1 Excerpt


M. M. Soniwala, P. R. Patel, N. S. Mansuri, R. K. Prikh, M. C. Gohel
J. Pharm. Sci. 67, 61 • 2005
View 1 Excerpt

Drug Develop

K.G.H. Desai
Res. 63, 33 • 2004


N. S. Thomas, R. Panchagnula
J. Pharm. Sci. 18, 71 • 2003
View 1 Excerpt


D. Layton, J. Riley, L. Wilton, S.A.W. Shakir
J. Pharm. Pract. 10, R 13 • 2002
View 1 Excerpt

Marrow J.D.: in The Pharmacological Basis of Therapeutics, Hardman J.E

L. R. Jacson
Limound L.E., Gilman A.G. Eds., • 2001
View 1 Excerpt

Drug Develop

S. P. Vyas, P. J. Gogoi, S. K. Jain
Ind. Pharm. 17 (8), 1047 • 1991

Drug Develop

B. Vennat, D. Gross, A. Pourrat, H. Pourrat
Ind. Pharm. 17, 2083 • 1991


W. I. Higuchi
Pharm. Sci. 51, 802 • 1962
View 1 Excerpt