Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system.

  title={Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system.},
  author={Azza A Hasan and Hafez Madkor and Sherief Wageh},
  journal={Drug delivery},
  volume={20 3-4},
Lactic acidosis is a serious, metabolic complication that may occur due to metformin hydrochloride (MH) accumulation during the treatment of diabetes mellitus. The aim of this study is to enhance the bioavailability of MH by oral route. Span 40 and cholesterol were used for the preparation of MH-loaded niosomes by the reverse phase evaporation technique. Dicetyl phosphate (DCP) and 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP) were used to obtain negatively and positively… CONTINUE READING


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