Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration

@article{Mathew2007FormulationAE,
  title={Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration},
  author={Sam Thomarayil Mathew and Selvaraju Gayathri Devi and K V Sandhya},
  journal={AAPS PharmSciTech},
  year={2007},
  volume={8},
  pages={E100-E108}
}
The objective of this work was to prepare and evaluate ketorolac tromethamine-loaded albumin microspheres using a factorial design. Albumin microspheres were prepared by emulsion cross-linking method. Selected formulations were characterized for their entrapment efficiency, particle size, surface morphology, and release behavior. Analysis of variance (ANOVA) for entrapment efficiency indicated that entrapment efficiency is best fitted to a response surface linear model. From the statistical… CONTINUE READING