Formulation and evaluation of gastroretentive microballoons containing baclofen for a floating oral controlled drug delivery system.

@article{Dube2014FormulationAE,
  title={Formulation and evaluation of gastroretentive microballoons containing baclofen for a floating oral controlled drug delivery system.},
  author={Tina Dube and Nisharani S. Ranpise and Arati N. Ranade},
  journal={Current drug delivery},
  year={2014},
  volume={11 6},
  pages={805-16}
}
The objective of the present study was to fabricate and evaluate a multiparticulate oral gastroretentive dosage form of baclofen characterized by a central large cavity (hollow core) promoting unmitigated floatation with practical applications to alleviate the signs and symptoms of spasticity and muscular rigidity. Solvent diffusion and evaporation procedure were applied to prepare floating microspheres with a central large cavity using various combinations of ethylcellulose (release retardant… CONTINUE READING
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