Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycobacterium avium infection.

@article{Oh1995FormulationAE,
  title={Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycobacterium avium infection.},
  author={Yung Keun Oh and D E David E Nix and Robert M Straubinger},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39 9},
  pages={2104-11}
}
Mycobacterium avium is an intracellular pathogen that can invade and multiply within macrophages of the reticuloendothelial system. Current therapy is not highly effective. Particulate drug carriers that are targeted to the reticuloendothelial system may provide a means to deliver antibiotics more efficiently to M. avium-infected cells. We investigated the formulation of the antibiotics ciprofloxacin and azithromycin in liposomes and tested their antibacterial activities in vitro against M… CONTINUE READING

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