Formulation and delivery of improved amorphous fenofibrate solid dispersions prepared by thin film freezing.

@article{Zhang2012FormulationAD,
  title={Formulation and delivery of improved amorphous fenofibrate solid dispersions prepared by thin film freezing.},
  author={Meimei Zhang and Houli Li and Bo Lang and Kevin O'Donnell and Haohao Zhang and Zhouhua Wang and Yixuan Dong and Chuanbin Wu and Robert O Williams},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2012},
  volume={82 3},
  pages={534-44}
}
The objective of this study was to prepare amorphous fenofibrate (FB) solid dispersions using thin film freezing (TFF) and to incorporate the solid dispersions into pharmaceutically acceptable dosage forms. FB solid dispersions prepared with optimized drug/polymer ratios were characterized by modulated differential scanning calorimetry (MDSC), powder X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) specific surface area measurements, Fourier-transform… CONTINUE READING

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