Formulation and characterization of hydrophilic drug diclofenac sodium-loaded solid lipid nanoparticles based on phospholipid complexes technology.

@article{Liu2014FormulationAC,
  title={Formulation and characterization of hydrophilic drug diclofenac sodium-loaded solid lipid nanoparticles based on phospholipid complexes technology.},
  author={Dongfei Liu and Limin Chen and Sunmin Jiang and Shuning Zhu and Yong Qian and Fengzhen Wang and Rui Li and Qunwei Xu},
  journal={Journal of liposome research},
  year={2014},
  volume={24 1},
  pages={
          17-26
        }
}
To successfully prepare the diclofenac sodium (DS)-loaded solid lipid nanoparticles (SLNs), phospholipid complexes (PCs) technology was applied here to improve the liposolubility of DS. Solid lipid nanoparticles (SLNs) loaded with phospholipid complexes (PCs) were prepared by the modified emulsion/solvent evaporation method. DS could be solubilized effectively in the organic solvents with the existence of phospholipid and apparent partition coefficient of DS in PCs increased significantly. X… CONTINUE READING

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