Formulation and characterization of poly(propylacrylic acid)/poly(lactic-co-glycolic acid) blend microparticles for pH-dependent membrane disruption and cytosolic delivery.

@article{Fernando2018FormulationAC,
  title={Formulation and characterization of poly(propylacrylic acid)/poly(lactic-co-glycolic acid) blend microparticles for pH-dependent membrane disruption and cytosolic delivery.},
  author={Lawrence P Fernando and Jamal S Lewis and Brian C. Evans and Craig L Duvall and Benjamin G Keselowsky},
  journal={Journal of biomedical materials research. Part A},
  year={2018},
  volume={106 4},
  pages={1022-1033}
}
Poly(lactic-co-glycolic acid) (PLGA) is widely used as a vehicle for delivery of pharmaceutically relevant payloads. PLGA is readily fabricated as a nano- or microparticle (MP) matrix to load both hydrophobic and hydrophilic small molecular drugs as well as biomacromolecules such as nucleic acids and proteins. However, targeting such payloads to the cell… CONTINUE READING