Formulation and characterization of a captopril ethyl ester drug-in-adhesive-type patch for percutaneous absorption

  title={Formulation and characterization of a captopril ethyl ester drug-in-adhesive-type patch for percutaneous absorption},
  author={D. Gullick and W. J. Pugh and M. Ingram and P. A. Cox and G. Moss},
  journal={Drug Development and Industrial Pharmacy},
  pages={926 - 932}
  • D. Gullick, W. J. Pugh, +2 authors G. Moss
  • Published 2010
  • Chemistry, Medicine
  • Drug Development and Industrial Pharmacy
  • Background: The ethyl ester of captopril has been shown to exhibit enhanced permeation across human skin compared to the parent drug. A drug-in-adhesive patch formulation of a captopril ethyl ester was therefore developed for optimum drug release. Method: A wide range of transdermal patches were prepared using two commercially available bioadhesive polymers. Investigational screening was conducted on the patches using microscopy, texture profile analysis, and infrared spectroscopy. Drug release… CONTINUE READING
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