Formulation Design, Preparation of Losartan Potassium Microsphers by Solvent Evaporation Method and it ́s in-vitro Characterization
- Arch Pharm Sci. & Res.,
The purpose of the present investigation was to formulate and evaluate micro encapsulated ramipril produced by the non aqueous emulsification solvent evaporation method microspheres were prepared using polymethacrylate polymers (Eudragit® RS100 and RL 100) and hypromellose (HPMC) by solvent evaporation method. The impacts of different factors such as stirring rate, polymer concentration,and volume at processing medium on the characteristics of the micro spheres were investisted.Microsphers were characterized for their surface morphology, particle size, drug entrapment efficiency and Invitro release study the morphology of microspheres was studied using scanning electron microscopy and it was shown that microspheres were spherical in nature. The particle size of microspheres analyzed by optical microscopic method & was affected by stirring rate, concentration of polymers and volume of processing medium. In vitro drug release. Studies it was found that the controlled effect of microspheres depended on the polymer concentration and type of polymers used in the formulation. The mechanism of drug release from the microspheres was found to be nonfickian type.