• Corpus ID: 212475891

Formulation and Evaluation of Taste Masked Fast Disintegrating Tablets of Sumatriptan Succinate

@inproceedings{Gawade2017FormulationAE,
  title={Formulation and Evaluation of Taste Masked Fast Disintegrating Tablets of Sumatriptan Succinate},
  author={Shilpa Gawade and Ashok V. Bhosale and Ravindra Y. Patil and Sujit Kakade},
  year={2017}
}
Sumatriptan Succinate is a potent and selective 5hydroxytryptamine agonist. It is an effective agent in the treatment of migraine. Sumatriptan Succinate undergoes extensive first pass metabolism with an oral bioavailability of approximately 15%. Thus, formulating Sumatriptan Succinate into a fast disintegrating tablets form would provide fast relief by rapid onset of action, improved oral bioavailability. Sumatriptan Succinate is extremely bitter in taste. The present research deals with… 

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The optimized tablet formulation showed better taste and the formulated sublingual tablets may act as a potential alternate for the Sumatriptan succinate oral tablet, and it was concluded that prepared formulation improve bioavailability by prevention of first pass metabolism.
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Formulation and Evaluation of Taste Masked Fast Disintegrating Tablet of Levocetirizine Dihydrochloride
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